Abstract

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.

Author affiliations

1. Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
2. Department of Human Genetics, University of California, Los Angeles, California 90095, USA.
3. Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA.

Correspondence to: Aldons J. Lusis^1,2 Email: jlusis@mednet.ucla.edu

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