Perspectives
Nature Reviews Genetics 9, 803-810 (October 2008) | doi:10.1038/nrg2431
Timeline: Trends in large-scale mouse mutagenesis: from genetics to functional genomics
Yoichi Gondo1 About the author
Abstract
The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins and rationale of these large-scale mouse mutagenesis programmes.
Author affiliations
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Yoichi Gondo is a member of the Mutagenesis and Genomics Team, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
Email: gondo@brc.riken.jp
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