Table of contents
July 2007 Vol 8 No 7
From the editors
p487 | doi:10.1038/nrg2148
Research Highlights
Epigenetics: Mapping the methylome without chips | PDF (103 KB)
p489 | doi:10.1038/nrg2147
Transcriptomics: Illuminating the dark matter of the genome | PDF (307 KB)
p490 | doi:10.1038/nrg2139
Cancer genetics: Finding needles in a haystack | PDF (220 KB)
p490 | doi:10.1038/nrg2150
In brief
Genomics | Chromosome biology | Human evolution | Network biology | PDF (83 KB)
p491 | doi:10.1038/nrg2155
Sociogenetics: Cheating gets you nowhere | PDF (165 KB)
p492 | doi:10.1038/nrg2138
In brief
RNA interference | Development | Epigenetics | Technology | PDF (88 KB)
p492 | doi:10.1038/nrg2156
Evolution: Interacting genes are more evolvable | PDF (108 KB)
p493 | doi:10.1038/nrg2153
Chromosome biology: Helping homologues to find their partners | PDF (105 KB)
p493 | doi:10.1038/nrg2154
Genomics: Resourcing the genome | PDF (84 KB)
p494 | doi:10.1038/nrg2151
Disease genetics: Onwards and upwards for genome-wide association studies | PDF (96 KB)
p494 | doi:10.1038/nrg2152
X inactivation: A time and a place to stay silent | PDF (206 KB)
p495 | doi:10.1038/nrg2140
Ethics watch
Benefit-sharing: a look at the history of an ethics concern | PDF (105 KB)
p496 | doi:10.1038/nrg2145
In the news
In the news | PDF (77 KB)
p496 | doi:10.1038/nrg2157
Reviews
Genetic linkage and association analyses for trait mapping in Plasmodium falciparum
Xinzhuan Su, Karen Hayton & Thomas E. Wellems
p497 | doi:10.1038/nrg2126
Malaria is a major cause of mortality in the developing world. Genetics and genomics are now greatly assisting our understanding of this disease, through linkage and association studies of the malaria parasite, Plasmodium.
The nuclear envelope and transcriptional control
Asifa Akhtar & Susan M. Gasser
p507 | doi:10.1038/nrg2122
The positioning of individual genes within the nucleus affects their expression levels. The inner face of the nuclear envelope is key to this method of regulating expression, with active genes preferentially locating to nuclear pores in a manner that might be heritable.
The versatile worm: genetic and genomic resources for Caenorhabditis elegans research
Igor Antoshechkin & Paul W. Sternberg
p518 | doi:10.1038/nrg2105
The popularity of Caenorhabditis elegans as a model organism is paralleled by the range of resources that are available to worm researchers. This Review provides a guide to existing C. elegans resources, and highlights areas for future development.
RNA regulons: coordination of post-transcriptional events
Jack D. Keene
p533 | doi:10.1038/nrg2111
RNA-binding proteins orchestrate the post-transcriptional co-regulation of subsets of mRNAs that encode functionally related proteins, thereby contributing to the coordination of gene expression in eukaryotes. Understanding the dynamics of such ribonucleoprotein structures might provide insights into some complex diseases and the regulation of gene expression during development.
Chromatin crosstalk in development and disease: lessons from REST
Lezanne Ooi & Ian C. Wood
p544 | doi:10.1038/nrg2100
REST can act as a hub for the recruitment of multiple chromatin-modifying enzymes. Research into its function and that of its corepressors has provided new insight into how chromatin-modifying proteins cooperate to regulate gene expression, and how alterations in this function cause disease.
Perspective
Opinion
Planar cell polarity: one or two pathways?
Peter A. Lawrence, Gary Struhl & José Casal
p555 | doi:10.1038/nrg2125
The prevailing view is that planar cell polarity is the outcome of one genetic pathway. On the basis of their observations in genetically mosaic adult flies, the authors challenge this assumption and discuss potentially far-reaching implications of their model.
