Review
Nature Reviews Genetics 8, 507-517 (July 2007) | doi:10.1038/nrg2122
The nuclear envelope and transcriptional control
Asifa Akhtar1 & Susan M. Gasser2 About the authors
Abstract
Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner.
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Author affiliations
- EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
- Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Correspondence to: Asifa Akhtar1 Email: Akhtar@embl.de
Correspondence to: Susan M. Gasser2 Email: susan.gasser@fmi.ch
Published online 5 June 2007
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