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Malaria is a major cause of mortality in the developing world. Genetics and genomics are now greatly assisting our understanding of this disease, through linkage and association studies of the malaria parasite,Plasmodium.
The positioning of individual genes within the nucleus affects their expression levels. The inner face of the nuclear envelope is key to this method of regulating expression, with active genes preferentially locating to nuclear pores in a manner that might be heritable.
The popularity ofCaenorhabditis elegans as a model organism is paralleled by the range of resources that are available to worm researchers. This Review provides a guide to existing C. elegansresources, and highlights areas for future development.
RNA-binding proteins orchestrate the post-transcriptional co-regulation of subsets of mRNAs that encode functionally related proteins, thereby contributing to the coordination of gene expression in eukaryotes. Understanding the dynamics of such ribonucleoprotein structures might provide insights into some complex diseases and the regulation of gene expression during development.
REST can act as a hub for the recruitment of multiple chromatin-modifying enzymes. Research into its function and that of its corepressors has provided new insight into how chromatin-modifying proteins cooperate to regulate gene expression, and how alterations in this function cause disease.
The prevailing view is that planar cell polarity is the outcome of one genetic pathway. On the basis of their observations in genetically mosaic adult flies, the authors challenge this assumption and discuss potentially far-reaching implications of their model.
