Epigenetics: Transcriptional memory remodelled

p323 | doi:10.1038/nrg2110

Evolution: Colour vision for mice

p324 | doi:10.1038/nrg2106

Technology: Driving out insect-borne pathogens

p324 | doi:10.1038/nrg2112

Circadian genetics: Setting the pace: three's company

p326 | doi:10.1038/nrg2115

Cancer genetics: Micro enhancement

p326 | doi:10.1038/nrg2116

RNA world: Dicer in the mammalian female germ line

p327 | doi:10.1038/nrg2120

Genome evolution: How old are Hox genes?

p328 | doi:10.1038/nrg2114

Evolution: Duplicates provide only limited cover

p328 | doi:10.1038/nrg2119

Gene expression: A not-so-passive spliceosome

p329 | doi:10.1038/nrg2113

Biology by numbers: mathematical modelling in developmental biology

Claire J. Tomlin & Jeffrey D. Axelrod

p331 | doi:10.1038/nrg2098

One promising way of attempting to understand the complexity of biological processes is to model them mathematically. Such models can help predict the wider biological effects of local interactions and are now producing testable hypotheses about the workings of developmental systems.

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Genetic determinants of cancer metastasis

Don X. Nguyen & Joan Massagué

p341 | doi:10.1038/nrg2101

Genome-wide technologies, functional experimentation in model systems and clinical validation are beginning to identify genetic and epigenetic alterations that underlie metastatic disease. These genetic determinants are distinct from those that mediate malignant transformation and can be classified into metastasis initiation, metastasis progression and metastasis virulence genes.

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Animal models of human disease: zebrafish swim into view

Graham J. Lieschke & Peter D. Currie

p353 | doi:10.1038/nrg2091

Animal models are crucial for understanding the pathogenesis of human disease and provide a system in which to develop and test new therapies. The zebrafish offers unique advantages over other vertebrates and is therefore rapidly emerging as a model organism for a wide range of human diseases, both genetic and acquired, and for therapeutic drug discovery and development.

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Gene function in mouse embryogenesis: get set for gastrulation

Patrick P. L. Tam & David A. F. Loebel

p368 | doi:10.1038/nrg2084

Successful gastrulation depends on a complex pattern of signalling and gene expression in the early embryo. Uniquely in mammals, this involves both embryonic and extraembryonic tissue. This Review examines how lineages are specified and cell movements are co-ordinated in the early mouse embryo.

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Hybrid necrosis: autoimmunity as a potential gene-flow barrier in plant species

Kirsten Bomblies & Detlef Weigel

p382 | doi:10.1038/nrg2082

Reduction in gene flow between varieties is part of the process of speciation. One underappreciated reason for such a reduction is hybrid necrosis — when the hybrid offspring have phenotypes that resemble the results of pathogen attack and environmental stress.

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