Review
Nature Reviews Genetics 8, 963-972 (December 2007) | doi:10.1038/nrg2227
There is a Corrigendum (July Issue) associated with this article.
Cooperation of signalling pathways in embryonic mammary gland development
Gertraud W. Robinson1 About the author
Abstract
Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
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Author affiliations
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Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892–20822, USA.
Email: traudl@nih.gov
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