Genomics: Copy number variation map | PDF (170 KB)

p2 | doi:10.1038/nrg2012

Development: It takes a lot to make the segmentation clock tick | PDF (159 KB)

p3 | doi:10.1038/nrg2028

Metagenomics: A global marine viral metagenome | PDF (159 KB)

p3 | doi:10.1038/nrg2030

Developmental biology: Unleashing regenerative potential | PDF (286 KB)

p4 | doi:10.1038/nrg2035

RNA world: Haploids and diploids make no sense of each other | PDF (286 KB)

p4 | doi:10.1038/nrg2036

Pathogen Genomics: Parasite diversity promises malaria secrets | PDF (224 KB)

p5 | doi:10.1038/nrg2034

Evolution: The first Dobzhansky–Muller pair | PDF (166 KB)

p6 | doi:10.1038/nrg2032

Mouse genomic technologies: Crossing the map | PDF (166 KB)

p6 | doi:10.1038/nrg2033

DNA replication: Telomeres are double trouble | PDF (125 KB)

p6 | doi:10.1038/nrg2037

DNA repair: Dedicated protection for the female germ line | PDF (184 KB)

p8 | doi:10.1038/nrg2029

Polycomb silencing mechanisms and the management of genomic programmes

Yuri B. Schwartz & Vincenzo Pirrotta

p9 | doi:10.1038/nrg1981

Recent progress has changed our view of how Polycomb group complexes are recruited and how they affect chromatin and repress gene activity. The authors review our current understanding of PcG mechanisms and their implications for the programming of gene expression in development.

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An evolutionary view of human recombination

Graham Coop & Molly Przeworski

p23 | doi:10.1038/nrg1947

Despite the key role of recombination in meiosis, increasing evidence indicates substantial variation in recombination rates among humans, and between humans and other mammals. Understanding the forces that shape this variation will require a combination of evolutionary and molecular perspectives.

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Heterochromatin revisited

Shiv I. S. Grewal & Songtao Jia

p35 | doi:10.1038/nrg2008

Heterochromatin was once considered the less-interesting part of the genome, the junk that had to be dealt with by being silenced. Recent studies in fission yeast indicate that heterochromatin has a role in various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.

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Dosage compensation: the beginning and end of generalization

Tobias Straub & Peter B. Becker

p47 | doi:10.1038/nrg2013

Gene expression levels are adjusted to compensate for the different numbers of sex chromosomes in males and females, although the mechanisms for doing this vary between species. Recent data show how dosage compensation is fine-tuned by modulating chromatin structure.

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The mouse as a model for human biology: a resource guide for complex trait analysis

Luanne L. Peters, Raymond F. Robledo, Carol J. Bult, Gary A. Churchill, Beverly J. Paigen & Karen L. Svenson

p58 | doi:10.1038/nrg2025

The mouse is a powerful model for elucidating the genetic basis of complex human traits and diseases. One reason for this is the wealth of available resources for mouse genetics that has been built up over the past 100 years.

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Innovations: Prenatal diagnosis: progress through plasma nucleic acids

Y. M. Dennis Lo & Rossa W. K. Chiu

p71 | doi:10.1038/nrg1982

Non-invasive techniques for prenatal diagnosis are extremely advantageous in terms of both safety and cost. The discovery of fetal nucleic acids in the maternal plasma has led to the development of many non-invasive tests.

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