Nature Reviews Genetics 7, 669-680 (September 2006) | doi:10.1038/nrg1941

Reconstructing human origins in the genomic era

Daniel Garrigan1 & Michael F. Hammer1  About the authors


Analyses of recently acquired genomic sequence data are leading to important insights into the early evolution of anatomically modern humans, as well as into the more recent demographic processes that accompanied the global radiation of Homo sapiens. Some of the new results contradict early, but still influential, conclusions that were based on analyses of gene trees from mitochondrial DNA and Y-chromosome sequences. In this review, we discuss the different genetic and statistical methods that are available for studying human population history, and identify the most plausible models of human evolution that can accommodate the contrasting patterns observed at different loci throughout the genome.

Author affiliations

  1. Division of Biotechnology, University of Arizona, Tucson AZ 85721, USA.

Correspondence to: Michael F. Hammer1 Email:


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