Quantitative genetics: A lean feat — microRNAs and muscle mass | PDF (155 KB)

p491 | doi:10.1038/nrg1898

Gene expression: A singular level of noise | PDF (118 KB)

p492 | doi:10.1038/nrg1897

Gene regulation: RNA-mediated inheritance spotted in mice | PDF (137 KB)

p492 | doi:10.1038/nrg1902

X inactivation: Random acts of silence | PDF (97 KB)

p494 | doi:10.1038/nrg1899

Sociogenetics: Beat the cheat | PDF (85 KB)

p494 | doi:10.1038/nrg1909

Epigenetics: Do mothers and fathers imprint differently? | PDF (116 KB)

p495 | doi:10.1038/nrg1907

Evolution: Looking for an advantage | PDF (127 KB)

p496 | doi:10.1038/nrg1900

RNA world: MIWI and MILI find small partners | PDF (121 KB)

p497 | doi:10.1038/nrg1908

Development: FGF8 — you're making my heart! | PDF (112 KB)

p497 | doi:10.1038/nrg1910

Alternative splicing and RNA selection pressure — evolutionary consequences for eukaryotic genomes

Yi Xing & Christopher Lee

p499 | doi:10.1038/nrg1896

High-throughput genomics data have provided a genome-wide picture of alternative splicing in multiple organisms. Genome sequencing and comparative genomics have revealed the evolutionary impact of alternative splicing and the constraints on evolution associated with the regulation of alternative splicing.

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A framework for community and ecosystem genetics: from genes to ecosystems

Thomas G. Whitham, Joseph K. Bailey, Jennifer A. Schweitzer, Stephen M. Shuster, Randy K. Bangert, Carri J. LeRoy, Eric V. Lonsdorf, Gery J. Allan, Stephen P. DiFazio, Brad M. Potts, Dylan G. Fischer, Catherine A. Gehring, Richard L. Lindroth, Jane C. Marks, Stephen C. Hart, Gina M. Wimp & Stuart C. Wooley

p510 | doi:10.1038/nrg1877

Genotypes act not only on individuals but on entire ecological communities. Although it is a complex undertaking, it is possible to extend population and quantitative genetics principles to understanding ecosystem processes, and place them in an evolutionary framework.

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Moving forward in reverse: genetic technologies to enable genome-wide phenomic screens in Arabidopsis

Jose M. Alonso & Joseph R. Ecker

p524 | doi:10.1038/nrg1893

With its genome sequenced, Arabidopsis thaliana — one of the main genetic model organisms — has moved into the functional genomic era. Classical forward genetic approaches are now being combined with reverse genetics to analyse the complete plant phenome — gene function on the genome scale.

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Genetic defects in the human glycome

Hudson H. Freeze

p537 | doi:10.1038/nrg1894

A growing number of diseases are known to result from genetic defects in glycosylation pathways. Recent studies have begun to reveal the diverse ways in which glycosylation defects can cause disease, and the many functions of the glycome.

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Primate segmental duplications: crucibles of evolution, diversity and disease

Jeffrey A. Bailey & Evan E. Eichler

p552 | doi:10.1038/nrg1895

Segmental duplications are emerging as key contributors to the evolution of primate genomes. Furthermore, determining how, and when, these duplications arose and diversified is proving to be an essential goal in understanding human phenotypic variation and disease susceptibility.

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Designed DNA molecules: principles and applications of molecular nanotechnology

Anne Condon

p565 | doi:10.1038/nrg1892

The sequence, structure and folding properties of DNA are being exploited in innovative ways, thereby expanding the uses of DNA beyond its natural calling. This article examines those applications, which range from disease diagnostics to molecular computing.

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