Review
Nature Reviews Genetics 7, 499-509 (July 2006) | doi:10.1038/nrg1896
Alternative splicing and RNA selection pressure — evolutionary consequences for eukaryotic genomes
Yi Xing1,2,3 & Christopher Lee1 About the authors
Abstract
Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in gene regulation in many organisms. Genome sequencing and comparative genomics have made it possible to look in detail at the evolutionary history of specific alternative exons or splice sites, resulting in a flurry of publications in recent years. Here, we consider how alternative splicing has contributed to the evolution of modern genomes, and discuss constraints on evolution associated with alternative splicing that might have important medical implications.
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Author affiliations
- Molecular Biology Institute, Center for Genomics and Proteomics, Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
- Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
- Department of Statistics, Stanford University, Sequoia Hall, 390 Serra Mall, Stanford, California 94305, USA.
Correspondence to: Christopher Lee1 Email: leec@mbi.ucla.edu
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