Nature Reviews Genetics 7, 482-488 (June 2006) | doi:10.1038/nrg1872

OpinionAddressing the problems with life-science databases for traditional uses and systems biology

Stephan Philippi1 & Jacob Köhler2  About the authors


A prerequisite to systems biology is the integration of heterogeneous experimental data, which are stored in numerous life-science databases. However, a wide range of obstacles that relate to access, handling and integration impede the efficient use of the contents of these databases. Addressing these issues will not only be essential for progress in systems biology, it will also be crucial for sustaining the more traditional uses of life-science databases.

Author affiliations

  1. Stephan Philippi is at the Department of Computer Science, University of Koblenz, PO Box 201602, 56016 Koblenz, Germany.
  2. Jacob Köhler is at the Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK.

Correspondence to: Stephan Philippi1 Email:

Published online 9 May 2006


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