Chromosome biology: The means to an end | PDF (101 KB)

p330 | doi:10.1038/nrg1862

RNA interference: Breakthrough for systemic RNAi | PDF (105 KB)

p331 | doi:10.1038/nrg1866

Gene regulation: A closer look at conservation | PDF (80 KB)

p332 | doi:10.1038/nrg1856

Technology: Complexity on the nanoscale | PDF (80 KB)

p332 | doi:10.1038/nrg1858

Human genetics: It's all in the balance | PDF (174 KB)

p333 | doi:10.1038/nrg1857

Gene regulation: Plastic switches | PDF (99 KB)

p334 | doi:10.1038/nrg1864

RNA world: Designer plant miRNAs meet their targets | PDF (110 KB)

p334 | doi:10.1038/nrg1865

Gene regulation: Compensation Culture | PDF (121 KB)

p335 | doi:10.1038/nrg1867

Reproduction: Unscrambling the egg–sperm divide | PDF (91 KB)

p336 | doi:10.1038/nrg1868

An integrated view of protein evolution

Csaba Pál, Balázs Papp & Martin J. Lercher

p337 | doi:10.1038/nrg1838

Many factors other than protein structure and function affect the rate of protein evolution. Advances in genomics make it possible to assess the contribution of all these factors and move towards a more integrated view of how proteins evolve.

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Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

Cécile Crosnier, Despina Stamataki & Julian Lewis

p349 | doi:10.1038/nrg1840

Stem-cell systems all raise similar kinds of issues concerning the nature of the niche and the differentiation process. Genetic studies of the intestinal stem-cell system have made strides in providing generally applicable answers to such questions.

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Mesoderm induction: from caps to chips

David Kimelman

p360 | doi:10.1038/nrg1837

Although major molecular players with a role in mesoderm induction have been identified, high-throughput approaches are beginning to yield data that will help us to understand how the embryo integrates and processes the various signals during mesoderm induction.

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High-throughput RNAi screening in cultured cells: a user's guide

Christophe J. Echeverri & Norbert Perrimon

p373 | doi:10.1038/nrg1836

Carrying out high-throughput, cell-based RNA interference screens involves making a range of decisions, from choosing the cell type and reagents to picking strategies for optimization and validation. Informed planning at each stage allows the power of this approach to be maximized.

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Family-based designs in the age of large-scale gene-association studies

Nan M. Laird & Christoph Lange

p385 | doi:10.1038/nrg1839

Although they are sometimes overlooked, family-based designs provide important advantages for detecting genetic associations in studies of complex disease. In particular, they provide a means of overcoming the problems that arise when multiple hypotheses are tested in genome-wide association studies.

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