Review

Nature Reviews Genetics 7, 211-221 (March 2006) | doi:10.1038/nrg1807

The evolution of spliceosomal introns: patterns, puzzles and progress

Scott William Roy1 & Walter Gilbert2  About the authors

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The origins and importance of spliceosomal introns comprise one of the longest-abiding mysteries of molecular evolution. Considerable debate remains over several aspects of the evolution of spliceosomal introns, including the timing of intron origin and proliferation, the mechanisms by which introns are lost and gained, and the forces that have shaped intron evolution. Recent important progress has been made in each of these areas. Patterns of intron-position correspondence between widely diverged eukaryotic species have provided insights into the origins of the vast differences in intron number between eukaryotic species, and studies of specific cases of intron loss and gain have led to progress in understanding the underlying molecular mechanisms and the forces that control intron evolution.

Author affiliations

  1. Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Palmerston North, New Zealand.
  2. 15 Gray Gardens West, Cambridge, Massachusetts 01238, USA.

Correspondence to: Scott William Roy1 Email: scottwroy@gmail.com

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