Review
Nature Reviews Genetics 7, 130-141 (February 2006) | doi:10.1038/nrg1769
Towards multidimensional genome annotation
Jennifer L. Reed1, Iman Famili2, Ines Thiele1 & Bernhard O. Palsson1 About the authors
Abstract
Our information about the gene content of organisms continues to grow as more genomes are sequenced and gene products are characterized. Sequence-based annotation efforts have led to a list of cellular components, which can be thought of as a one-dimensional annotation. With growing information about component interactions, facilitated by the advancement of various high-throughput technologies, systemic, or two-dimensional, annotations can be generated. Knowledge about the physical arrangement of chromosomes will lead to a three-dimensional spatial annotation of the genome and a fourth dimension of annotation will arise from the study of changes in genome sequences that occur during adaptive evolution. Here we discuss all four levels of genome annotation, with specific emphasis on two-dimensional annotation methods.
- View At a Glance
Author affiliations
- Department of Bioengineering, University of California, San Diego, La Jolla, California, 92093, USA.
- Genomatica Inc., 5405 Morehouse Drive, Suite 210, San Diego, California 92121, USA.
Correspondence to: Bernhard O. Palsson1 Email: palsson@ucsd.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
TCR avidity: it's not how strong you make it, it's how you make it strongNature Immunology News and Views (01 Aug 2001)
RESEARCH
Functional antigen-independent synapses formed between T cells and dendritic cellsNature Immunology Article (01 Oct 2001)
A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic informationMolecular Systems Biology Article (26 Jun 2007)
Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeriMolecular Systems Biology Article (31 Jan 2006)
See all 14 matches for Research
