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Review
Nature Reviews Genetics 7, 917–928 (1 December 2006) | doi:10.1038/nrg1944
Genetics of autoimmune diseases |[mdash]| disorders of immune homeostasis
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Abstract
In the past few years, our extensive knowledge of the mammalian immune system and our increasing ability to understand the genetic causes of complex human disease have opened a window onto the pathways that lead to autoimmune disorders. In addition to the well-established role of genetic variation that affects the major histocompatibility complex, a number of rare and common variants that affect a range of immunological pathways are now known to have important influences on the phenotypic diversity that is seen among autoimmune diseases. Recent studies have also highlighted a previously unanticipated interplay between the innate and adaptive immune system, providing a new direction for research in this field.
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