Table of contents
Research Highlights
Chemical genomics: Joining the small-molecule dots | PDF (124 KB)
p822 | doi:10.1038/nrg1995
Genetic variation: Recombination's local role revealed | PDF (183 KB)
p823 | doi:10.1038/nrg1993
In brief
Sex chromosomes | Evolution | Technology | Genome evolution | PDF (97 KB)
p823 | doi:10.1038/nrg1998
RNA interference: A discriminating position | PDF (278 KB)
p824 | doi:10.1038/nrg1983
Developmental biology: Homeobox genes: eyeing the clock | PDF (117 KB)
p824 | doi:10.1038/nrg1996
In the news
X prize for express sequencing | PDF (81 KB)
p824 | doi:10.1038/nrg2002
In brief
Small RNAs | Cloning | Developmental genetics | Disease Genetics | PDF (96 KB)
p825 | doi:10.1038/nrg1999
Network biology: Wiring with a difference | PDF (255 KB)
p826 | doi:10.1038/nrg1986
Genome Sequencing: Into the woods | PDF (164 KB)
p826 | doi:10.1038/nrg1987
Epigenomics: The first genome-wide methylome | PDF (200 KB)
p827 | doi:10.1038/nrg1994
Gene regulation: A 4C approach to gene interactions in 3D | PDF (137 KB)
p828 | doi:10.1038/nrg2000
Evolutionary genetics: Converge and diversify | PDF (88 KB)
p828 | doi:10.1038/nrg2001
Reviews
The genetic dissection of essential hypertension
Allen W. Cowley, Jr
p829 | doi:10.1038/nrg1967
Complex physiological inputs and environmental influences have made mapping genetic determinants of hypertension susceptibility particularly challenging. Refining results from previous studies in both rats and humans, combined with new genome-wide approaches, is set to accelerate progress in this area.
Orchestrating ontogenesis: variations on a theme by sonic hedgehog
Philip W. Ingham & Marysia Placzek
p841 | doi:10.1038/nrg1969
The sonic hedgehog signalling molecule controls development at many stages and by different mechanisms. This article uses it to exemplify the fundamental mechanisms by which developmental growth and patterning are regulated in both vertebrates and invertebrates.
Speciation genetics: evolving approaches
Mohamed A. F. Noor & Jeffrey L. Feder
p851 | doi:10.1038/nrg1968
Genomic techniques have pervaded studies of speciation genetics. Although they might not have led to changes in the prevailing hypotheses, the accelerated pace of data collection and compilation should help us to understand the relative frequency and importance of the different processes that cause speciation.
Genetics of global gene expression
Matthew V. Rockman & Leonid Kruglyak
p862 | doi:10.1038/nrg1964
The recently emerged field of genetic analysis of global gene expression has shed light on the architecture of quantitative traits, transcriptional regulation and regulatory variation. It has provided a way of connecting DNA sequence variation with phenotypic variation.
Bridging the regeneration gap: genetic insights from diverse animal models
Alejandro Sánchez Alvarado & Panagiotis A. Tsonis
p873 | doi:10.1038/nrg1923
Studies of regenerative biology have been hampered by a lack of tools for testing gene function in traditional model species. Recent advances have overcome this problem, leading to new insights into both basic regenerative biology and its biomedical potential.
Perspectives
Opinion
A gene-centric approach to genome-wide association studies
Eric Jorgenson & John S. Witte
p885 | doi:10.1038/nrg1962
The ability to provide information about variants in genes is crucial to genome-wide association studies. This article argues that the currently available marker sets are unlikely to provide adequate coverage of genic variants, and suggests how this problem could be overcome.
Article series: Historical Profiles
Timeline
Gavin Rylands de Beer: how embryology foreshadowed the dilemmas of the genome
Tim J. Horder
p892 | doi:10.1038/nrg1918
Misleading views of embryology led to the marginalization of this field in the first half of the twentieth century. Gavin de Beer was partly responsible for introducing a genetic perspective to evo–devo, and anticipated continuing problems for molecular genetics.
Erratum: Primate segmental duplications: crucibles of evolution, diversity and disease
Jeffrey A. Bailey & Evan E. Eichler
| doi:10.1038/nrg1997
