Review
Nature Reviews Genetics 6, 669-677 (September 2005) | doi:10.1038/nrg1673
Replication and transcription: Shaping the landscape of the genome
Lyubomira Chakalova1, Emmanuel Debrand1, Jennifer A. Mitchell1, Cameron S. Osborne1 & Peter Fraser1 About the authors
Abstract
As the relationship between nuclear structure and function begins to unfold, a picture is emerging of a dynamic landscape that is centred on the two main processes that execute the regulated use and propagation of the genome. Rather than being subservient enzymatic activities, the replication and transcriptional machineries provide potent forces that organize the genome in three-dimensional nuclear space. Their activities provide opportunities for epigenetic changes that are required for differentiation and development. In addition, they impose physical constraints on the genome that might help to shape its evolution.
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Author affiliations
- Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom.
Correspondence to: Peter Fraser1 Email: peter.fraser@bbsrc.ac.uk
Published online 10 August 2005
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