Nature Reviews Genetics 6, 271-286 (April 2005) | doi:10.1038/nrg1576

Strategies for mapping and cloning quantitative trait genes in rodents

Jonathan Flint1, William Valdar1, Sagiv Shifman1 & Richard Mott1  About the authors


Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin–Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents.

Author affiliations

  1. Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

Correspondence to: Jonathan Flint1 Email:


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