Review
Nature Reviews Genetics 6, 206-220 (March 2005) | doi:10.1038/nrg1555
Induction and suppression of RNA silencing: insights from viral infections
Olivier Voinnet1 About the author
Abstract
In eukaryotes, small RNA molecules engage in sequence-specific interactions to inhibit gene expression by RNA silencing. This process fulfils fundamental regulatory roles, as well as antiviral functions, through the activities of microRNAs and small interfering RNAs. As a counter-defence mechanism, viruses have evolved various anti-silencing strategies that are being progressively unravelled. These studies have not only highlighted our basic understanding of host–parasite interactions, but also provide key insights into the diversity, regulation and evolution of RNA-silencing pathways.
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Author affiliations
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Institut de Biologie Moléculaire des Plantes du CNRS, 12 Rue du Général Zimmer, 67084 Strasbourg Cedex, France.
Email: olivier.voinnet@ibmp-ulp.u-strasbg.fr
Published online 10 February 2005
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