Review
Nature Reviews Genetics 6, 881-892 (December 2005) | doi:10.1038/nrg1723
Focus on: The body plan
The genesis and evolution of homeobox gene clusters
Jordi Garcia-Fernàndez1 About the author
Abstract
Once called the 'Rosetta stone' of developmental biology, the homeobox continues to fascinate both evolutionary and developmental biologists. The birth of the homeotic, or Hox, gene cluster, and its subsequent evolution, has been crucial in mediating the major transitions in metazoan body plan. Comparative genomics studies indicate that the more recently discovered ParaHox and NK clusters were linked to the Hox cluster early in evolution, and that together they constituted a 'megacluster' of homeobox genes that conspicuously contributed to body-plan evolution.
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Author affiliations
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Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, España.
Email: jordigarcia@ub.edu
Published online 10 November 2005
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