Review
Nature Reviews Genetics 6, 847-846 (November 2005) | doi:10.1038/nrg1707
Genotyping errors: causes, consequences and solutions
François Pompanon1, Aurélie Bonin1, Eva Bellemain1 & Pierre Taberlet1 About the authors
Abstract
Although genotyping errors affect most data and can markedly influence the biological conclusions of a study, they are too often neglected. Errors have various causes, but their occurrence and effect can be limited by considering these causes in the production and analysis of the data. Procedures that have been developed for dealing with errors in linkage studies, forensic analyses and non-invasive genotyping should be applied more broadly to any genetic study. We propose a protocol for estimating error rates and recommend that these measures be systemically reported to attest the reliability of published genotyping studies.
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Author affiliations
- Laboratoire d'Ecologie Alpine, UMR CNRS 5553, Université Joseph Fourier, B.P. 53, 38041 Grenoble Cedex 9, France.
Correspondence to: François Pompanon1 Email: francois.pompanon@ujf-grenoble.fr
Published online 27 September 2005
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