Perspectives
Nature Reviews Genetics , 766-773 | doi:10.1038/nrg1686
Subject Category: History of genetic disease
Focus on: Repeat Instability
History of genetic disease: The molecular genetics of Huntington disease — a history
Gillian P. Bates1 About the author
Abstract
The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years later the pathogenic mutation was identified as a CAG-repeat expansion. Our current understanding of the molecular pathogenesis of Huntington disease could never have been achieved without the recent progress in the field of molecular genetics. We are now equipped with powerful genetic models that continue to uncover new aspects of the pathogenesis of Huntington disease and will be instrumental for the development of therapeutic approaches for this disease.
Author affiliations
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Gillian P. Bates is at the Department of Medical and Molecular Genetics, GKT School of Medicine, King's College London, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom.
Email: gillian.bates@genetics.kcl.ac.uk
Published online 31 August 2005
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