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Review
Nature Reviews Genetics 5, 262–275 (1 April 2004) | doi:10.1038/nrg1317
Chemogenomics: an emerging strategy for rapid target and drug discovery
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Abstract
Chemogenomics is an emerging discipline that combines the latest tools of genomics and chemistry and applies them to target and drug discovery. Its strength lies in eliminating the bottleneck that currently occurs in target identification by measuring the broad, conditional effects of chemical libraries on whole biological systems or by screening large chemical libraries quickly and efficiently against selected targets. The hope is that chemogenomics will concurrently identify and validate therapeutic targets and detect drug candidates to rapidly and effectively generate new treatments for many human diseases.
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