Review
Nature Reviews Genetics 5, 923-935 (December 2004) | doi:10.1038/nrg1490
When sugars guide axons: insights from heparan sulphate proteoglycan mutants
Jeong-Soo Lee1 & Chi-Bin Chien1 About the authors
Abstract
Although there have previously been hints that heparan sulphate proteoglycans (HSPGs) are important for axon guidance, as they are for many other biological processes, there has been little in vivo evidence for interaction with known axon-guidance pathways. Genetic analyses of fly, mouse, nematode and zebrafish mutants now confirm the role of HSPGs in axon guidance and are beginning to show that they might have a key role in modulating the action of axon-guidance ligands and receptors.
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Author affiliations
- Department of Neurobiology and Anatomy, University of Utah School of Medicine, 20 North 1900 East, Salt Lake City, Utah 84132, USA.
Correspondence to: Chi-Bin Chien1 Email: chi-bin.chien@neuro.utah.edu
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