FIGURE 5 | A simplified view of eukaryotic translation initiation.

From the following article:

The power of the 3' UTR: translational control and development

Scott Kuersten & Elizabeth B. Goodwin

Nature Reviews Genetics 4, 626-637 (August 2003)


The power of the 3|[prime]| UTR: translational control and development

The 40S ribosomal subunit (blue) assembles with eukaryotic initiation factor 2 (eIF2), GTP and initiator methionyl tRNA to form the 43S pre-initiation complex (red). The eIF4F complex (purple) (which includes eIF4E, the cytoplasmic cap-binding protein and eIF4G, a protein that binds directly to and recruits the 40S subunit), together with 43S, is then recruited to the 5' cap. Poly(A) binding protein (PAB; yellow) bound to the poly(A) tail facilitates translation initiation by communicating with the 5' end of the mRNA through its interaction with eIF4G, effectively joining the 5' and 3' ends of the mRNA. The 43S complex then scans the mRNA until the AUG codon is recognized. This triggers eIF5 to hydrolyze GTP, the eIFs dissociate and the 60S subunit joins resulting in a fully functional ribosome that is ready to begin peptide synthesis. 7mG, 7N-methyl-8-hydroguanosine-5'-monophosphate; ORF, open reading frame.

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