Nature Reviews Genetics 4, 613-625 (August 2003) | doi:10.1038/nrg1126

Technicolour transgenics: imaging tools for functional genomics in the mouse

Anna-Katerina Hadjantonakis1, Mary E. Dickinson2, Scott E. Fraser2 & Virginia E. Papaioannou1  About the authors


Over the past decade, a battery of powerful tools that encompass forward and reverse genetic approaches have been developed to dissect the molecular and cellular processes that regulate development and disease. The advent of genetically-encoded fluorescent proteins that are expressed in wild type and mutant mice, together with advances in imaging technology, make it possible to study these biological processes in many dimensions. Importantly, these technologies allow direct visual access to complex events as they happen in their native environment, which provides greater insights into mammalian biology than ever before.

Author affiliations

  1. Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York 10032, USA.
  2. Beckman Institute, California Institute of Technology, Pasadena, California 91125, USA.

Correspondence to: Anna-Katerina Hadjantonakis1 Email: