Review
Nature Reviews Genetics 4, 598-612 (August 2003) | doi:10.1038/nrg1124
The human Y chromosome: an evolutionary marker comes of age
Mark A. Jobling1 & Chris Tyler-Smith2 About the authors
Abstract
Until recently, the Y chromosome seemed to fulfil the role of juvenile delinquent among human chromosomes — rich in junk, poor in useful attributes, reluctant to socialize with its neighbours and with an inescapable tendency to degenerate. The availability of the near-complete chromosome sequence, plus many new polymorphisms, a highly resolved phylogeny and insights into its mutation processes, now provide new avenues for investigating human evolution. Y-chromosome research is growing up.
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Author affiliations
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Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
Email: maj4@le.ac.uk -
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Email: cts@sanger.ac.uk
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