Review
Nature Reviews Genetics 4, 587-597 (August 2003) | doi:10.1038/nrg1123
Haplotype blocks and linkage disequilibrium in the human genome
Jeffrey D. Wall1,2 & Jonathan K. Pritchard1 About the authors
Abstract
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.
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Author affiliations
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Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA.
Email: jwall@genetics.bsd.uchicago.edu -
Current address:Program in Molecular and Computational Biology, The University of Southern California, 1042 West 36th Place, DRB 289, Los Angeles, California 90089-1113, USA.
pritch@uchicago.edu
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