Review
Nature Reviews Genetics 4, 497-507 (July 2003) | doi:10.1038/nrg1109
Looking back to the embryo: defining transcriptional networks in adult myogenesis
Maura H. Parker1,2,3, Patrick Seale1,2,4 & Michael A. Rudnicki2 About the authors
Abstract
Skeletal muscle has an intrinsic capacity for regeneration following injury or exercise. The presence of adult stem cells in various tissues with myogenic potential provides new opportunities for cell-based therapies to treat muscle disease. Recent studies have shown a conserved transcriptional hierarchy that regulates the myogenic differentiation of both embryonic and adult stem cells. Importantly, the molecules and signalling pathways that induce myogenic determination in the embryo might be manipulated or mimicked to direct the differentiation of adult stem cells either in vivo or ex vivo.
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Author affiliations
- These authors contributed equally to this paper.
- Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
- Faculty of Health Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
- Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Correspondence to: Michael A. Rudnicki2 Email: mrudnicki@ohri.ca
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