Review
Nature Reviews Genetics 4, 87-98 (February 2003) | doi:10.1038/nrg998
The chicken as a model for large-scale analysis of vertebrate gene function
William R. A. Brown1, Simon J. Hubbard2, Cheryll Tickle3 & Stuart A. Wilson2 About the authors
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Abstract
The chicken has been an important experimental system for developmental biology, immunology and microbiology, having led to many fundamental discoveries. The increase in genomic resources, easy access to the embryo and the application of RNA interference mean that it will be easy and quick to use chick embryos to screen the function of many genes during embryonic development. So, it seems likely that the chicken will increasingly be the system of choice for many vertebrate biologists who are interested in gene function.
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Author affiliations
- Institute of Genetics, Nottingham University, Queen's Medical Centre, Nottingham NG7 2UH, UK.
- Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology (UMIST), PO Box 88, Manchester M60 1QD, UK.
- School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.