Perspectives
Nature Reviews Genetics 4, 145-151 (February 2003) | doi:10.1038/nrg996
Opinion: Studying complex biological systems using multifactorial perturbation
Ritsert C. Jansen1 About the author
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Abstract
High-throughput genomics, transcriptomics, proteomics and metabolomics have the potential to identify the functional consequences of induced and natural genetic variation. Surprisingly, the experiments of most genomics researchers still mainly involve perturbing a biological system of interest by modifying either one factor or one gene at a time. By contrast, this article argues that multifactorial experimentation would allow the study of many more biologically relevant questions in parallel at the same or lower cost.
Author affiliations
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Ritsert C. Jansen is at the Groningen Bioinformatics Centre, the Institute of Mathematics and Computing Science, Faculty of Mathematical and Natural Sciences, and the Department of Medical Genetics, Faculty of Medical Sciences, University of Groningen, PO Box 800, NL-9700AV Groningen, The Netherlands.
Email: r.c.jansen@cs.rug.nl
