Review
Nature Reviews Genetics 4, 763-773 (October 2003) | doi:10.1038/nrg1178
From developmental disorder to heritable cancer: it's all in the BMP/TGF-
family
Kristin A. Waite1 & Charis Eng1,2,3 About the authors
Abstract
Transforming growth factor-
(TGF-) regulates many cellular processes through complex signal-transduction pathways that have crucial roles in normal development. Disruption of these pathways can lead to a range of diseases, including cancer. Mutations in the genes that encode members of the TGF- pathway are involved in vascular diseases as well as gastrointestinal neoplasia. More recently, they have been implicated in Cowden syndrome, which is normally associated with mutations in the phosphatase and tensin homologue gene PTEN. Molecular studies of TGF- signalling are now showing why mutations in genes that encode components of this pathway result in inherited cancer and developmental diseases.
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Author affiliations
- Human Cancer Genetics and Clinical Cancer Genetics Programs, Comprehensive Cancer Center, Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
- Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
- Cancer Research UK Human Cancer Genetics Research Group, University of Cambridge, Cambridge CB2 2XZ, UK.
Correspondence to: Charis Eng1,2,3 Email: eng-1@medctr.osu.edu
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