Review
Nature Reviews Genetics 3, 533-543 (July 2002) | doi:10.1038/nrg842
Subject Category: Organogenesis
Focus on: Organogenesis
Organogenesis: Coordinating early kidney development: lessons from gene targeting
Seppo Vainio1 & Yanfeng Lin2 About the authors
Abstract
The kidney is widely used to study the mechanisms of organogenesis. Its development involves fundamental processes, such as epithelial branching, induced morphogenesis and cytodifferentiation, which are common to the development of many other organs. Gene-targeting experiments have greatly improved our understanding of kidney development, and have revealed many important genes that regulate early kidney organogenesis, some of which have a role in inherited human kidney disorders. Although our understanding of how the kidney is assembled is still limited, these studies are beginning to provide insights into the genetic and cellular interactions that regulate early organogenesis.
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Author affiliations
- Biocenter Oulu and Department of Biochemistry, Linnanmaa, Faculties of Science and Medicine, University of Oulu, P.O. Box 3000, FIN-90014, Finland.
- Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Correspondence to: Seppo Vainio1 Email: seppo.vainio@oulu.fi
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