Review
Nature Reviews Genetics 3, 380-390 (May 2002) | doi:10.1038/nrg795
Genealogical trees, coalescent theory and the analysis of genetic polymorphisms
Noah A. Rosenberg1 & Magnus Nordborg1 About the authors
Abstract
Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.
- View At a Glance
Author affiliations
- Program in Molecular and Computational Biology, University of Southern California, 835 West 37th Street, SHS172, Los Angeles, California 90089-1340, USA.
Correspondence to: Magnus Nordborg1 Email: magnus@usc.edu
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
