FIGURE 1 | Integrating data from the rat and mouse for studies of human disease.

Through the study of comparative genomics, physiological, genetic and phenotypic data from the rat and mouse model organisms can be used to inform studies of human disease by providing candidate loci and gene-function data for gene-hunting studies. One of the primary advantages of the rat as a model organism is the amount of physiological and pharmacological information that is available for it. Inbred and transgenic strains of rat also provide models with clinically relevant phenotypes for the testing of new therapeutics. One of the key advantages of the mouse as a model organism is the availability of gene-knockout technology. ENU, ethylnitrosourea; QTL, quantitative trait loci.

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