Nature Reviews Genetics
Figure 5 FLASH ANIMATION
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Figure 5 | A model for X inactivation.
The model indicates speculative roles of some of the proposed players in
the initiation of X inactivation. a | Before inactivation, Xist
RNA is expressed in an unstable form (dotted red lines) and the postulated
blocking factor(s) (red) prevents Xist upregulation and/or its association
with the chromosome in cis. b | Xist RNA becomes upregulated
through stabilization, transcriptional upregulation or release of the blocking
factor. LINEs might participate in the spreading process in some way
either through association with nucleoprotein complexes including Xist
or by a mechanism such as
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