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Precision medicine is a strategy for tailoring clinical decision making to the underlying genetic causes of disease. This Review describes how, despite the straightforward overall principles of precision medicine, adopting it responsibly into clinical practice will require many technical and conceptual hurdles to be overcome. Such challenges include optimized sequencing strategies, clinically focused bioinformatics pipelines and reliable metrics for the disease causality of genetic variants.
Marine vertebrates are key contributors to global biodiversity and human food supply. In this Review, the authors discuss how comparative genomics studies in marine vertebrates have provided insight into major evolutionary transitions between the land and sea, as well as intra-species adaptation to diverse types of aquatic environments. They also highlight applications in species management and conservation.
The authors review the history of, and recent progress towards, mapping genes for type 2 diabetes mellitus (T2D), discuss the consequent implications for disease genetic architecture and propose open and interactive sharing of data by an integrated T2D web portal as a new research paradigm to hasten clinical translation of genetic discoveries.
Evidence is emerging that transcription factors (TFs) lacking methyl-CpG binding domains can interact with methylated DNA. This Analysis article reviews thein vitro and in vivoevidence for methylation-mediated interactions between TFs and DNA, and their functional consequences.
In this Opinion article, the authors discuss important questions relating to the study ofde novo genes. They discuss the challenges of identifying de novogenes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution.
