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Post transcriptional regulation

Chimeric protein production

Nature Reviews Genetics volume 13, pages 450–451 (2012)Cite this article

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generating chimeric transcripts could be a mechanism for altering the localization of the translated protein

First, the authors analysed previously reported human tissue RNA sequencing (RNA-seq) data sets for the presence of chimeric reads: that is, those reads that do not align to annotated transcripts and that include a chimeric exon–exon junction. This approach confirmed the expression of 175 out of 7,424 previously reported chimeric transcripts from 16 human tissues. Analysis of the level of expression of these transcripts revealed that although chimeric transcripts are themselves expressed at a low level, they incorporate transcripts that are normally expressed at a high level. They are also expressed in a highly tissue-specific manner.

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ORIGINAL RESEARCH PAPER

  1. Frenkel-Morgenstern, M. et al. Chimeras taking shape: potential functions of proteins encoded by chimeric RNA transcripts. Genome Res. 15 May 2012 (doi:10.1101/gr.130062.111)

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  1. Hannah Stower
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Stower, H. Chimeric protein production. Nat Rev Genet 13, 450–451 (2012). https://doi.org/10.1038/nrg3268

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  • DOI: https://doi.org/10.1038/nrg3268

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