In this study, the evolutionary forces acting on four wild populations of the house mouse Mus musculus were analysed by high-density SNP-genotyping arrays. Statistical analysis showed evidence for selective sweeps at rare and newly mutated alleles, indicating positive selection. Furthermore, positive selection was shown to result in a high percentage of introgression, resulting in the permanent incorporation of genetic material from one subspecies to another. Thus, introgression of haplotypes has a larger role in adaptive processes than was previously thought.
ORIGINAL RESEARCH PAPER
Staubach, F. et al. Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus). PLoS Genet. 8, e1002891 (2012)
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Stower, H. Introgression in natural populations. Nat Rev Genet 13, 675 (2012). https://doi.org/10.1038/nrg3343
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DOI: https://doi.org/10.1038/nrg3343