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'Omics' is in the eye of the beholder 'Omics' technologies are transforming many subfields of genetics, but their success depends on interesting hypotheses and good scientific judgement.
This article compares the different approaches that have been developed for detecting confounding due to population stratification, family structure and cryptic relatedness, with an emphasis on the potential of mixed models for addressing these problems simultaneously.
The recent sequencing of the genomes of diverse bacteria at different stages of host adaptation is leading to the revision of concepts in microbial evolutionary genomics that were based on studies of laboratory strains. New insights into genetic changes and selective pressures are emerging.
A huge range of genome-scale data sets — including genomic, epigenomic and transcriptomic information — are now available, and it is widely acknowledged that combining several data sets can provide important biological insights. However, there are practical, conceptual and computational challenges to data integration.
Which pressures shape the evolution of genomes and phenomes? Using data from comparative genomics and systems biology, the authors analyse this vast field, highlighting the variety of forces at work in addition to some universal themes.
Genotype imputation is an important tool for genome-wide association studies as it increases power, aids in fine-mapping of associations and facilitates meta-analyses. This Review provides a guide to and comparison of imputation methods and discusses association testing using imputed data.
The recent availability of sequence data from many yeast species has provided important insights into our understanding of the evolutionary mechanisms in this organism and other eukaryotes. This progress is discussed here, with a focus on the evolution of diverse yeast genome architectures and the multiphyletic origins of yeast among fungi.
