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Nature Reviews Genetics 10, 512–513 (1 August 2009) | doi:10.1038/nrg2647

Gene regulation: Sequence, chromatin, action!

Louisa Flintoft

When a cell receives a signal that alters its transcriptional programme, primary response genes (PRGs) are rapidly induced. Two recent papers provide new insights into the basis of the speedy activation of mammalian PRGs.