Table of contents

From the editors

p507 | doi:10.1038/nrg2648


Research Highlights

Complex disease: Schizophrenia: missing heritability found? | PDF (165 KB)

p509 | doi:10.1038/nrg2643

MicroRNAs: HITS-CLIP hits the microRNA target | PDF (201 KB)

p510 | doi:10.1038/nrg2635

Regeneration: Flies get into renewal | PDF (246 KB)

p510 | doi:10.1038/nrg2637

Technology: The sequencing game | PDF (132 KB)

p510 | doi:10.1038/nrg2646

In brief

X inactivation | Genome annotation | Epigenetics | Evolution | PDF (131 KB)

p511 | doi:10.1038/nrg2644

Evolution: Turning up the heat | PDF (175 KB)

p512 | doi:10.1038/nrg2638

Gene regulation: Sequence, chromatin, action! | PDF (147 KB)

p512 | doi:10.1038/nrg2647

Cell signalling: Telomerase gets Wnt talking | PDF (153 KB)

p513 | doi:10.1038/nrg2642

Evolution: Protein kinases mix it up | PDF (153 KB)

p514 | doi:10.1038/nrg2639

In brief

Phylogenetics | Technology | Epigenetics | Transcriptomics | PDF (104 KB)

p514 | doi:10.1038/nrg2645



Article series: Modelling

Quantitative approaches in developmental biology

Andrew C. Oates, Nicole Gorfinkiel, Marcos González-Gaitán & Carl-Philipp Heisenberg

p517 | doi:10.1038/nrg2548

This article describes the growing and invaluable contribution that quantitative mathematical frameworks are making to generating and testing hypotheses in developmental biology, and in shaping new ways of understanding developmental processes across molecular, cellular and tissue scales.

Fitness and its role in evolutionary genetics

H. Allen Orr

p531 | doi:10.1038/nrg2603

The concept of fitness is fundamental to understanding natural selection, but defining and measuring fitness involves some subtle distinctions. This Review explains theoretical aspects of fitness, introduces current experimental approaches and highlights issues that remain unresolved.

Article series: Modelling

Evolutionary analysis of the dynamics of viral infectious disease

Oliver G. Pybus & Andrew Rambaut

p540 | doi:10.1038/nrg2583

The rapid evolution of many important pathogens, particularly RNA viruses, means that their ecological and evolutionary dynamics occur on the same timescale. This Review discusses the insights into the transmission and epidemiology of viruses that have been provided by analyses of their evolutionary dynamics across a wide range of biological scales.

Mechanisms of change in gene copy number

P. J. Hastings, James R. Lupski, Susan M. Rosenberg & Grzegorz Ira

p551 | doi:10.1038/nrg2593

Copy number variation is a major source of variation between individuals that is increasingly recognized as influencing genome evolution and human disease. But how does it arise? The authors discuss predicted mechanisms of copy number change, including non-homologous end-joining and non-homologous repair of broken replication forks.

The genetics of quantitative traits: challenges and prospects

Trudy F. C. Mackay, Eric A. Stone & Julien F. Ayroles

p565 | doi:10.1038/nrg2612

Understanding the basis of phenotypic variation is one of the most challenging problems in biology. The arrival of high-throughput genomic technologies now looks set to allow an integrative systems genetic approach to dissecting the genetic component of complex traits.




Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

Brian D. Brown & Luigi Naldini

p578 | doi:10.1038/nrg2628

Constructs containing artificial microRNA target sites have the potential to improve a range of therapeutic strategies that are based on gene delivery or viruses. The same technology can be used for experimental purposes, in animal transgenics and to study the functions of microRNAs.