Review
Nature Reviews Genetics 10, 431-442 (July 2009) | doi:10.1038/nrg2594
The genetic contribution to non-syndromic human obesity
Andrew J. Walley1, Julian E. Asher1 & Philippe Froguel1,2 About the authors
Abstract
The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan era, the obvious question is how to improve the results obtained so far using single nucleotide polymorphism markers and how to move successfully into the other areas of genomic variation that may be associated with common obesity.
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Author affiliations
- Section of Genomic Medicine, Imperial College London, Burlington-Danes Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
- CNRS8090-Institute of Biology, Pasteur Institute, 1 Rue du Professeur Calmette, 59019 Lille, France.
Correspondence to: Andrew J. Walley1 Email: a.walley@imperial.ac.uk
Correspondence to: Philippe Froguel1,2 Email: p.froguel@imperial.ac.uk
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