Abstract

Genome-wide association studies have recently identified ten common genetic variants associated with colorectal cancer susceptibility, several suggesting the involvement of components of the transforming growth factor beta (TGF) superfamily signalling pathway. To date, no causal sequence variants have been identified, and risk seems to be mediated through effects on gene regulation. Several markers are located close to poorly characterized genes or in gene deserts, raising challenges for elucidating mechanisms of susceptibility. Disease-associated common genetic variation offers the potential to refine risk stratification within populations and enable more targeted disease prevention strategies.

Author affiliations

1. Albert Tenesa and Malcolm G. Dunlop are at the Colon Cancer Genetics Group, University of Edinburgh and MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, 4th Floor MRC Human Genetics Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK.
   Email: Albert.Tenesa@ed.ac.uk
   Email: Malcolm.Dunlop@hgu.mrc.ac.uk

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.