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Nature Reviews Genetics 10, 151 (1 March 2009) | doi:10.1038/nrg2542

Chromatin: Completing the picture

Meera Swami

Characterizing the proteins that bind to and regulate specific genes is crucial for understanding gene regulation. A new method called proteomics of isolated chromatin segments (PiCh) promises to accelerate progress in this area, by allowing the full complement of proteins that bind to a particular gene to be assayed in a single experiment.