Review
Nature Reviews Genetics 10, 161-172 (March 2009) | doi:10.1038/nrg2522
Nucleosome positioning and gene regulation: advances through genomics
Cizhong Jiang1 & B. Franklin Pugh1 About the authors
Abstract
Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP–chip and ChIP–Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning.
- View At a Glance
Author affiliations
- Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Correspondence to: B. Franklin Pugh1 Email: bfp2@psu.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Labile H3.3+H2A.Z nucleosomes mark 'nucleosome-free regions'Nature Genetics News and Views (01 Aug 2009)
RESEARCH
Nucleosome organization in the Drosophila genomeNature Article (15 May 2008)
RSC regulates nucleosome positioning at Pol II genes and density at Pol III genesThe EMBO Journal Article (09 Jan 2008)
Nucleosome positions predicted through comparative genomicsNature Genetics Letter (01 Oct 2006)
See all 64 matches for Research
