Current Issue
December 2009 Vol 10 No 12
Also this month:
From the editors
p813 | doi:10.1038/nrg2716
Research Highlights
Evolution: The routes of adaptation | PDF (114 KB)
p815 | doi:10.1038/nrg2706
Chromatin: Mapping genome-wide chromosome interactions | PDF (147 KB)
p816 | doi:10.1038/nrg2701
Development: Size control by divide and rule | PDF (149 KB)
p816 | doi:10.1038/nrg2709
Ageing: The impact of shrinking telomeres | PDF (138 KB)
p816 | doi:10.1038/nrg2711
In brief
Sequencing technologies | Development | Population genetics | PDF (121 KB)
p817 | doi:10.1038/nrg2713
Epigenetics: An expanding horizon for DNA methylation | PDF (143 KB)
p818 | doi:10.1038/nrg2702
Sex determination: The means to discriminate | PDF (177 KB)
p818 | doi:10.1038/nrg2704
In brief
Human disease | Gene regulatory networks | Genetics of gene expression | PDF (135 KB)
p819 | doi:10.1038/nrg2714
Speciation: New insights into hybrid sterility | PDF (138 KB)
p820 | doi:10.1038/nrg2705
Gene expression: Regulators hidden in human proteome | PDF (202 KB)
p820 | doi:10.1038/nrg2708
Reviews
Generating specificity and diversity in the transcriptional response to hypoxia
Urban Lendahl, Kian Leong Lee, Henry Yang & Lorenz Poellinger
p821 | doi:10.1038/nrg2665
In addition to the core hypoxic transcriptional pathway, several mechanisms exist to allow transcriptional diversity and specificity. This Review highlights recent advances in our understanding of the mechanisms and factors that contribute to the tailoring of the appropriate hypoxic transcriptional response.
Article series: Applications of next-generation sequencing
The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs
Alain Jacquier
p833 | doi:10.1038/nrg2683
Recent transcriptomic studies have revealed that diverse small RNAs are transcribed from the regions around gene promoters. This Review considers questions prompted by the discovery of these transcripts; for example, what is their origin and are they functional?
Vertebrate limb bud development: moving towards integrative analysis of organogenesis
Rolf Zeller, Javier López-Ríos & Aimée Zuniga
p845 | doi:10.1038/nrg2681
Vertebrate limb development is a classic developmental model. In this Review the authors discuss how existing models of this process might be integrated and might form a framework for a systems approach to understanding organogenesis.
Article series: Modelling
Synthetic biology: understanding biological design from synthetic circuits
Shankar Mukherji & Alexander van Oudenaarden
p859 | doi:10.1038/nrg2697
The article highlights how the process of engineering biological systems has contributed to our understanding of how endogenous systems are put together and function — from a quantitative description of gene expression and signal transduction to controlling spatial organization and cell–cell interactions.
Perspectives
Article series: Genome-wide association studies
Opinion
Common disorders are quantitative traits
Robert Plomin, Claire M. A. Haworth & Oliver S. P. Davis
p872 | doi:10.1038/nrg2670
Results from genome-wide association studies support the view that qualitative disorders can be interpreted as being the extremes of quantitative dimensions. Research on quantitative traits could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
Viewpoint
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
Juan Carlos Izpisúa Belmonte, James Ellis, Konrad Hochedlinger & Shinya Yamanaka
p878 | doi:10.1038/nrg2700
Four leading researchers contribute their personal opinions on recent progress and current challenges in induced pluripotent stem cell research. Their varied perspectives suggest that for clinical applications there is cause for optimism, tempered with caution, and they highlight exciting recent advances in reprogramming and differentiation.
Corrigendum: Genetic and molecular insights into the development and evolution of sexual dimorphism
Thomas M. Williams & Sean B. Carroll
p883 | doi:10.1038/nrg2710
Corrigendum: Common disorders are quantitative traits
Robert Plomin, Claire M. A. Haworth & Oliver S. P. Davis
p883 | doi:10.1038/nrg2715
