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Research Highlights

Nature Reviews Genetics 10, 820 (1 December 2009) | doi:10.1038/nrg2708

Gene expression: Regulators hidden in human proteome

Tanita Casci

A search for DNA–protein interactions has unexpectedly pulled out over 300 human proteins that are known for other biological roles. By highlighting the multitasking function of many human proteins, this work provides a new perspective on the molecular basis of organismal complexity.