Recombination: Piecing regulation together | PDF (219 KB)

p737 | doi:10.1038/nrg2685

Development: Splitting off | PDF (172 KB)

p738 | doi:10.1038/nrg2688

Pharmacogenetics: A SNP for hepatitis C treatment failure | PDF (142 KB)

p738 | doi:10.1038/nrg2690

Chromosome biology: Small RNAs find the centre | PDF (156 KB)

p739 | doi:10.1038/nrg2692

Human genomics: Structural variation catches up | PDF (165 KB)

p740 | doi:10.1038/nrg2686

Development: Remembering Hedgehog | PDF (140 KB)

p740 | doi:10.1038/nrg2691

Small RNAs: Budding new models for RNAi | PDF (144 KB)

p741 | doi:10.1038/nrg2682

Evolution: No turning back | PDF (157 KB)

p742 | doi:10.1038/nrg2699

Spatial patterns of variation due to natural selection in humans

John Novembre & Anna Di Rienzo

p745 | doi:10.1038/nrg2632

Although humans are genetically similar, marked geographic patterns exist for many heritable traits. The investigation of spatial patterns at loci under selection can address fundamental questions about geographically variable traits in humans and give new insights into human adaptation.

• Abstract
• Full Text
• PDF (820 KB)

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

James E. Cleaver, Ernest T. Lam & Ingrid Revet

p756 | doi:10.1038/nrg2663

Inherited mutations in the nucleotide excision DNA repair pathway cause an unusually diverse range of clinical abnormalities; even mutations in the same gene can cause markedly different phenotypes. Recent structural, genetic and clinical studies are helping to explain this variability.

• Abstract
• Full Text
• PDF (826 KB)

Genetics of motor neuron disorders: new insights into pathogenic mechanisms

Patrick A. Dion, Hussein Daoud & Guy A. Rouleau

p769 | doi:10.1038/nrg2680

Dozens of new genes with causal roles in motor neuron diseases have recently been identified, which has moved the field beyond the previous focus on superoxide dismutase 1 mutations. These findings implicate several additional pathways in motor neuron diseases, including RNA processing, axonal transport and mitochondrial function.

• Abstract
• Full Text
• PDF (690 KB)
• Supplementary information

The genetics of inbreeding depression

Deborah Charlesworth & John H. Willis

p783 | doi:10.1038/nrg2664

The genetic basis of inbreeding depression and of the related phenomenon, heterosis, has been a puzzle for many decades. Based on recent studies in many species, the authors argue that both phenomena are predominantly caused by the presence of recessive deleterious mutations in populations.

• Abstract
• Full Text
• PDF (450 KB)

Genetic and molecular insights into the development and evolution of sexual dimorphism

Thomas M. Williams & Sean B. Carroll

p797 | doi:10.1038/nrg2687

Increasing evidence suggests that animal sexual dimorphisms are produced by the combined action of transcriptional effectors of sex-determination pathways and other transcription factors on cis-regulatory elements. These findings have led to new insights into how differences between sexes evolve.

• Abstract
• Full Text
• PDF (496 KB)